The Psychiatric CNS and Psychiatric NP working in Massachusetts have opportunities to inform and refer our most challenging clients with severe lifelong depression to those who are on the cutting edge of treatment. The Psychiatric CNS and Psychiatric NP will be encountering clients with implants in the near future. We have a role in continuing therapy and conventional treatment in those with implants who can now expect a higher quality of life. Psychiatric APRN’s will have opportunities to help clients form new life goals that they might have not imagined and use their capabilities to live the life they always intended to live. Novel treatments provide the opportunity to reduce the burden of illness. Psych APRN’s will be key in giving therapy and care to those emerging from a painful past and reducing the impact of depressive habits that could interfere with achieving optimum outcomes.